A Formal Synthesis of (+)-Hannokinol Using a Chiral Horner–Wittig Reagent

Michael Tapera; Federica Borghi; Jan Lukas Mayer-Figge; Fabia Mittendorf; Ibrahim-Ethem Celik; Adrián Gómez-Suárez; Stefan F. Kirsch

doi:10.3390/molecules29153710

Molecules (Aug 2024)

A Formal Synthesis of (+)-Hannokinol Using a Chiral Horner–Wittig Reagent

Michael Tapera,
Federica Borghi,
Jan Lukas Mayer-Figge,
Fabia Mittendorf,
Ibrahim-Ethem Celik,
Adrián Gómez-Suárez,
Stefan F. Kirsch

Affiliations

Michael Tapera: Organic Chemistry, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany
Federica Borghi: Organic Chemistry, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany
Jan Lukas Mayer-Figge: Organic Chemistry, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany
Fabia Mittendorf: Organic Chemistry, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany
Ibrahim-Ethem Celik: Organic Chemistry, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany
Adrián Gómez-Suárez: Organic Chemistry, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany
Stefan F. Kirsch: Organic Chemistry, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany

DOI: https://doi.org/10.3390/molecules29153710
Journal volume & issue: Vol. 29, no. 15
p. 3710

Abstract

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Herein, we report a concise and efficient formal synthesis of (+)-hannokinol. Key to this new strategy is the use of a chiral Horner–Wittig reagent, readily available from 2-deoxy-D-ribose, to introduce the chiral 1,3-diol motif.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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