Dietary Mannan Oligosaccharides Modulate Gut Inflammatory Response and Improve Duodenal Villi Height in Post-Weaning Piglets Improving Feed Efficiency
Alessandro Agazzi,
Vera Perricone,
Fabio Omodei Zorini,
Silvia Sandrini,
Elena Mariani,
Xian-Ren Jiang,
Alessandra Ferrari,
Maurizio Crestani,
Thi Xuan Nguyen,
Valentino Bontempo,
Cinzia Domeneghini,
Giovanni Savoini
Affiliations
Alessandro Agazzi
Department of Health, Animal Science and Food Safety “Carlo Cantoni” (VESPA), Università degli Studi di Milano, Via dell’Università 6, 26900 Lodi, Italy
Vera Perricone
Department of Health, Animal Science and Food Safety “Carlo Cantoni” (VESPA), Università degli Studi di Milano, Via dell’Università 6, 26900 Lodi, Italy
Fabio Omodei Zorini
Department of Health, Animal Science and Food Safety “Carlo Cantoni” (VESPA), Università degli Studi di Milano, Via dell’Università 6, 26900 Lodi, Italy
Silvia Sandrini
Department of Health, Animal Science and Food Safety “Carlo Cantoni” (VESPA), Università degli Studi di Milano, Via dell’Università 6, 26900 Lodi, Italy
Elena Mariani
Dipartimento di Scienze Medico-Veterinaire, Univeristy of Parma, Via del Taglio 10, 43126 Parma, Italy
Xian-Ren Jiang
Feed Research Institute, Chinese Academy of Agricultural Sciences, Zhongguancun South Street 12, Beijing 100081, China
Alessandra Ferrari
Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy
Maurizio Crestani
Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy
Thi Xuan Nguyen
Department of Health, Animal Science and Food Safety “Carlo Cantoni” (VESPA), Università degli Studi di Milano, Via dell’Università 6, 26900 Lodi, Italy
Valentino Bontempo
Department of Health, Animal Science and Food Safety “Carlo Cantoni” (VESPA), Università degli Studi di Milano, Via dell’Università 6, 26900 Lodi, Italy
Cinzia Domeneghini
Department of Health, Animal Science and Food Safety “Carlo Cantoni” (VESPA), Università degli Studi di Milano, Via dell’Università 6, 26900 Lodi, Italy
Giovanni Savoini
Department of Health, Animal Science and Food Safety “Carlo Cantoni” (VESPA), Università degli Studi di Milano, Via dell’Università 6, 26900 Lodi, Italy
The aim of this study was to evaluate the effects of mannan oligosaccharides (MOS) on gut health and performance in post-weaning piglets. In total, 40 piglets were divided into two experimental groups and fed a basal diet with (TRT) or without (CON) 0.2% mannan oligosaccharides for 35 days. Growth performance was determined weekly and faecal microbial composition on days 0, 14 and 35. On day 36, histometrical evaluations were performed on duodenal, jejunal, ileal, and colon samples. mRNA gene expression of inflammation-related genes was evaluated in samples of ileal Peyer’s patches (IPP). MOS administration improved feed efficiency in the last two weeks of the trial (p p = 0.05). TRT piglets showed increased duodenal villi height (p p p < 0.01) in IPP. Our results suggest beneficial effects of MOS supplementation on gut morphology and the expression of inflammation-related genes in post-weaning piglets, accompanied by increased feed efficiency.
