Data on the involvement of Meox1 in balloon-injury-induced neointima formation of rats
Bing Wu,
Lei Zhang,
Yun-He Zhu,
You-en Zhang,
Fei Zheng,
Jian-Ye Yang,
Ling-Yun Guo,
Xing-Yuan Li,
Lu Wang,
Jun-Ming Tang,
Shi-You Chen,
Jia-Ning Wang
Affiliations
Bing Wu
Institute of Clinical Medicine and Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, People's Republic of China; Key Lab of Human Embryonic Stem Cell of Hubei Province and Department of Physiology, Hubei University of Medicine, Hubei 442000, China
Lei Zhang
Institute of Clinical Medicine and Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, People's Republic of China; Key Lab of Human Embryonic Stem Cell of Hubei Province and Department of Physiology, Hubei University of Medicine, Hubei 442000, China
Yun-He Zhu
Department of Nuclear Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, People's Republic of China
You-en Zhang
Institute of Clinical Medicine and Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, People's Republic of China
Fei Zheng
Institute of Clinical Medicine and Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, People's Republic of China; Key Lab of Human Embryonic Stem Cell of Hubei Province and Department of Physiology, Hubei University of Medicine, Hubei 442000, China
Jian-Ye Yang
Institute of Clinical Medicine and Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, People's Republic of China; Key Lab of Human Embryonic Stem Cell of Hubei Province and Department of Physiology, Hubei University of Medicine, Hubei 442000, China
Ling-Yun Guo
Institute of Clinical Medicine and Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, People's Republic of China; Key Lab of Human Embryonic Stem Cell of Hubei Province and Department of Physiology, Hubei University of Medicine, Hubei 442000, China
Xing-Yuan Li
Institute of Clinical Medicine and Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, People's Republic of China; Key Lab of Human Embryonic Stem Cell of Hubei Province and Department of Physiology, Hubei University of Medicine, Hubei 442000, China
Lu Wang
Institute of Clinical Medicine and Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, People's Republic of China; Key Lab of Human Embryonic Stem Cell of Hubei Province and Department of Physiology, Hubei University of Medicine, Hubei 442000, China
Jun-Ming Tang
Institute of Clinical Medicine and Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, People's Republic of China; Key Lab of Human Embryonic Stem Cell of Hubei Province and Department of Physiology, Hubei University of Medicine, Hubei 442000, China
Shi-You Chen
Department of Physiology & Pharmacology, The University of Georgia, Athens, GA 30602, USA
Jia-Ning Wang
Institute of Clinical Medicine and Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, People's Republic of China; Key Lab of Human Embryonic Stem Cell of Hubei Province and Department of Physiology, Hubei University of Medicine, Hubei 442000, China; Corresponding author at: Institute of Clinical Medicine and Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, People's Republic of China. Fax: +86 719/8637792.
In the previous report, Meox1 was found to promote SMCs phenotypic modulation and injury-induced vascular remodeling by regulating the FAK-ERK1/2-autophagy signaling cascade (Wu et al., 2017) [1]. Here, we presented new original data on the involvement of Mesoderm/mesenchyme homeobox gene l (Meox1) in balloon-injury-induced neointima formation of rat. In rat carotid artery balloon injury model to induce vascular remodeling, Meox1 was induced in vascular smooth muscle cell (SMCs) of rat carotid arteries. Most proliferating cell nuclear antigen (PCNA)-positive cells also expressed Meox1. These data suggested that Meox1 may be involved in SMCs proliferation during injury-induced neointima formation. Furthermore, knocked down its expression in injured arteries by adenoviral delivery of Meox1 short hairpin RNA (shRNA) (shMeox1), neointima formation was significantly inhibited. Elastin staining also confirmed the reduction of neointima in Meox1 shRNA-transduced arteries. Moreover, knockdown of Meox1 decreased the collagen production/deposition that was significantly increased in neointima induced by balloon injury. Keywords: Meox1, SMCs, Balloon-injury, Neointimal formation
