Enterovirus Transmission by Secretory Autophagy

Abstract

Present in many cell types, non-degradative secretory autophagy is a newly discovered pathway in which autophagosomes fuse with the plasma membrane instead of lysosomes. Surprisingly, some viruses exploit secretory autophagy to exit cells non-lytically, shedding into the extracellular environment as particle populations contained within vesicles. As a result, this significantly enhances the infectivity of these viruses. In this paper, this novel cellular exit pathway is highlighted and its advantages for viral transmission discussed.

Keywords

• secretory autophagy
• picornavirus
• enterovirus
• poliovirus
• Coxsackievirus
• rhinovirus
• syntaxin 17
• viral transmission
• quasispecies
• RNA virus