Nature Communications (Jul 2016)

Human NK cell development requires CD56-mediated motility and formation of the developmental synapse

  • Emily M. Mace,
  • Justin T. Gunesch,
  • Amera Dixon,
  • Jordan S. Orange

DOI
https://doi.org/10.1038/ncomms12171
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

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CD56, a splicing variant of NCAM, marks human NK cell differentiation stages. Here the authors show that developing human NK cells form CD56-enriched synapses with stromal cells, and CD56 is critical to promote motility of NK cells that increases with their maturation.