Current Issues in Molecular Biology (Dec 2022)

Design, Synthesis, Characterization, and Analysis of Antimicrobial Property of Novel Benzophenone Fused Azetidinone Derivatives through In Vitro and In Silico Approach

  • Lakshmi Ranganatha Venkataravanappa,
  • Mahima Jyothi,
  • Hussien Ahmed Khamees,
  • Ekaterina Silina,
  • Victor Stupin,
  • Raghu Ram Achar,
  • Mohammed Al-Ghorbani,
  • Shaukath Ara Khanum

DOI
https://doi.org/10.3390/cimb45010007
Journal volume & issue
Vol. 45, no. 1
pp. 92 – 109

Abstract

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A sequence of novel 2-(4-benzoyl-2-methyl-phenoxy)-N-(3-chloro-2-oxo-4-phenyl-azetidin-1-yl)-acetamide analogues 9(a–n) were synthesized by multistep synthesis. The newly synthesized compounds were well characterized, and their antimicrobial activities were carried out by disc diffusion and broth dilution methods. Further, all the novel series of compounds (9a–n), were tested against a variety of bacterial and fungal strains in comparison to Ketoconazole, Chloramphenicol, and Amoxicillin as standard drugs, respectively. Compounds 9a, 9e, and 9g as a lead molecule demonstrated a good inhibition against tested strains. Further, molecular docking studies have been performed for the potent compounds to check the three-dimensional geometrical view of the ligand binding to the targeted proteins.

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