Use of IV immunoglobulin to treat steroid resistant, immune checkpoint inhibitor‐induced pure red cell aplasia: A case report

Abstract

Abstract Pure red cell aplasia (PRCA) is characterised by normocytic normochromic anaemia, reticulocytopenia and reduced erythroid precursors in bone marrow. PRCA as an immune‐related adverse event secondary to immune checkpoint inhibitor (ICI) therapy is rare. Steroids are usually used first line to treat ICI‐induced PRCA. Here, we report a case of ICI‐induced PRCA with no response to steroids but where intravenous (IV) immunoglobulin was successfully used second line. ICI therapy was reinitiated following PRCA resolution. PRCA recurrence did not occur.

Keywords

• immune checkpoint inhibitor
• immune‐related adverse events
• IV immunoglobulin
• pure red cell aplasia