Interplay of the transcription factor MRTF-A and matrix stiffness controls mammary acinar structure and protrusion formation

Marie-Luise Melcher; Ines Block; Karolin Kropf; Anurag Kumar Singh; Guido Posern

doi:10.1186/s12964-022-00977-2

Cell Communication and Signaling (Oct 2022)

Interplay of the transcription factor MRTF-A and matrix stiffness controls mammary acinar structure and protrusion formation

Marie-Luise Melcher,
Ines Block,
Karolin Kropf,
Anurag Kumar Singh,
Guido Posern

Affiliations

Marie-Luise Melcher: Institute for Physiological Chemistry, Medical Faculty, Martin Luther University Halle-Wittenberg
Ines Block: Institute for Physiological Chemistry, Medical Faculty, Martin Luther University Halle-Wittenberg
Karolin Kropf: Institute for Physiological Chemistry, Medical Faculty, Martin Luther University Halle-Wittenberg
Anurag Kumar Singh: Institute for Physiological Chemistry, Medical Faculty, Martin Luther University Halle-Wittenberg
Guido Posern: Institute for Physiological Chemistry, Medical Faculty, Martin Luther University Halle-Wittenberg

DOI: https://doi.org/10.1186/s12964-022-00977-2
Journal volume & issue: Vol. 20, no. 1
pp. 1 – 13

Abstract

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Highlights Formation of mammary acini depends on crosstalk between matrix stiffness and MRTF-A Increased matrix stiffness elevates MRTF-A activity and protrusion formation Protrusion formation of MCF10A-derived and primary murine acini is MRTF-dependent Genetic MRTF-A activation in primary organoids is sufficient for luminal filling

Published in Cell Communication and Signaling

ISSN: 1478-811X (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine; Science: Biology (General): Cytology
Website: https://biosignaling.biomedcentral.com/

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Abstract

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