Nature Communications (May 2020)
PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies
- Shivani Bhatt,
- Ansel T. Hillmer,
- Matthew J. Girgenti,
- Aleksandra Rusowicz,
- Michael Kapinos,
- Nabeel Nabulsi,
- Yiyun Huang,
- David Matuskey,
- Gustavo A. Angarita,
- Irina Esterlis,
- Margaret T. Davis,
- Steven M. Southwick,
- Matthew J. Friedman,
- Traumatic Stress Brain Study Group,
- Ronald S. Duman,
- Richard E. Carson,
- John H. Krystal,
- Robert H. Pietrzak,
- Kelly P. Cosgrove
Affiliations
- Shivani Bhatt
- Interdepartmental Neuroscience Program, Yale University
- Ansel T. Hillmer
- Department of Radiology and Biomedical Imaging, Yale School of Medicine
- Matthew J. Girgenti
- Department of Psychiatry, Yale School of Medicine
- Aleksandra Rusowicz
- Department of Psychiatry, Yale School of Medicine
- Michael Kapinos
- Yale PET Center, Yale School of Medicine
- Nabeel Nabulsi
- Department of Radiology and Biomedical Imaging, Yale School of Medicine
- Yiyun Huang
- Department of Radiology and Biomedical Imaging, Yale School of Medicine
- David Matuskey
- Department of Radiology and Biomedical Imaging, Yale School of Medicine
- Gustavo A. Angarita
- Department of Psychiatry, Yale School of Medicine
- Irina Esterlis
- Interdepartmental Neuroscience Program, Yale University
- Margaret T. Davis
- Department of Psychiatry, Yale School of Medicine
- Steven M. Southwick
- Department of Psychiatry, Yale School of Medicine
- Matthew J. Friedman
- Neurosciences Center, Dartmouth Medical School
- Traumatic Stress Brain Study Group
- Ronald S. Duman
- Department of Psychiatry, Yale School of Medicine
- Richard E. Carson
- Department of Radiology and Biomedical Imaging, Yale School of Medicine
- John H. Krystal
- Department of Psychiatry, Yale School of Medicine
- Robert H. Pietrzak
- Department of Psychiatry, Yale School of Medicine
- Kelly P. Cosgrove
- Interdepartmental Neuroscience Program, Yale University
- DOI
- https://doi.org/10.1038/s41467-020-15930-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Neuroinflammation has been proposed to accompany the peripheral inflammation observed in PTSD. Here, authors find lower in vivo and postmortem levels of neuroimmune marker TSPO (translocator protein) in PTSD, in association with greater PTSD severity and higher plasma CRP.
