Nature Communications (Jul 2021)

SS18 regulates pluripotent-somatic transition through phase separation

  • Junqi Kuang,
  • Ziwei Zhai,
  • Pengli Li,
  • Ruona Shi,
  • Wenjing Guo,
  • Yuxiang Yao,
  • Jing Guo,
  • Guoqing Zhao,
  • Jiangpin He,
  • Shuyang Xu,
  • Chuman Wu,
  • Shengyong Yu,
  • Chunhua Zhou,
  • Linlin Wu,
  • Yue Qin,
  • Baomei Cai,
  • Wei Li,
  • Zichao Wu,
  • Xiaoxi Li,
  • Shilong Chu,
  • Tingting Yang,
  • Bo Wang,
  • Shangtao Cao,
  • Dongwei Li,
  • Xiaofei Zhang,
  • Jiekai Chen,
  • Jing Liu,
  • Duanqing Pei

DOI
https://doi.org/10.1038/s41467-021-24373-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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Emerging evidence suggests that exit from pluripotency is a regulated, rather than passive process. Here the authors identify a requirement for SS18-mediated Brg/Brahma-associated factors (BAF) chromatin remodeling complex assembly during exit from pluripotency, and that SS18 promotes BAF assembly through liquidliquid phase separation.