A Practical and Economical Route to (S)-Glycidyl Pivalate

Abstract

An efficient method to prepare enantiopure (S)-glycidyl pivalate from (R)-epichlorohydrin and pivalic acid is reported. This work provides an alternative to the synthesis of this important building block from readily available and inexpensive materials.

Keywords

• tuberculosis
• api
• pretomanid
• epichlorohydrin
• supply centered synthesis