SynOpen (Oct 2022)

A Practical and Economical Route to (S)-Glycidyl Pivalate

  • Jeffrey M. Noble,
  • Le Chang,
  • Dan Chen,
  • Binglin Wang,
  • Raymond N. Dominey,
  • Daniel W. Cook,
  • Justina M. Burns,
  • Rodger W. Stringham,
  • Flavio S. P. Cardoso,
  • David R. Snead

DOI
https://doi.org/10.1055/s-0042-1751375
Journal volume & issue
Vol. 06, no. 04
pp. 258 – 262

Abstract

Read online

An efficient method to prepare enantiopure (S)-glycidyl pivalate from (R)-epichlorohydrin and pivalic acid is reported. This work provides an alternative to the synthesis of this important building block from readily available and inexpensive materials.

Keywords