Pleiotropic genetic architecture and novel loci for C-reactive protein levels

Fotios Koskeridis; Evangelos Evangelou; Saredo Said; Joseph J. Boyle; Paul Elliott; Abbas Dehghan; Ioanna Tzoulaki

doi:10.1038/s41467-022-34688-6

Nature Communications (Nov 2022)

Pleiotropic genetic architecture and novel loci for C-reactive protein levels

Fotios Koskeridis,
Evangelos Evangelou,
Saredo Said,
Joseph J. Boyle,
Paul Elliott,
Abbas Dehghan,
Ioanna Tzoulaki

Affiliations

Fotios Koskeridis: Department of Hygiene and Epidemiology, University of Ioannina Medical School
Evangelos Evangelou: Department of Hygiene and Epidemiology, University of Ioannina Medical School
Saredo Said: Nuffield Department of Population Health, University of Oxford
Joseph J. Boyle: National Heart and Lung Institute, Imperial College London
Paul Elliott: Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
Abbas Dehghan: Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
Ioanna Tzoulaki: Department of Hygiene and Epidemiology, University of Ioannina Medical School

DOI: https://doi.org/10.1038/s41467-022-34688-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

Read online

Chronic inflammation and lipometabolism share many causal genes and possibly pathways. Here, the authors use a multi-trait GWAS approach to study shared genetic determinants of low-grade inflammation, measured by C-reactive protein (CRP), and closely linked lipid and metabolic pathways.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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