Effect of renal denervation on the arterial stiffness and central hemodynamics in patients with resistant hypertension

Abstract

Aim: to evaluate the effect of renal denervation (RDN) on the stiffness of the aorta and major arteries, central blood pressure and index augmentation in patients with resistant hypertension. Material and methods. We included 20 patients with systolic blood pressure 178 [170; 180] mm Hg and diastolic blood pressure 100 [94; 100] mm Hg on 5.1±0.7 antihypertensive drugs with diuretic, who underwent bilateral RDN. Blood pressure (BP) was studied before intervention, at 7 days and 6 months after RDN by tree methods: office BP, 24-hour ambulatory blood pressure (ABPM) and aortic BP with applanation tonometry a. radialis (SphygmoCor). All patients were divided into two groups by ABPM in 6 months after RDN: responders (decrease of mean ABPM≥5 mm Hg) and non-responders (decrease of mean ABPM<5 mm Hg). Arterial stiffness parameters were measured with carotid-femoral pulse wave velocity (PWVcf), cardio-ankle vascular index (CAVI) and index augmentation (AIx). Result. RDN significantly decrease office BP in a majority of patients with resistant hypertension, but significantly improved central aortic pressure and arterial stiffness only in responders to RDN.

Keywords

• refractory arterial hypertension
• renal arteries denervation
• central blood pressure
• arterial stiffness
• pulse wave velocity