Frontiers in Cellular Neuroscience (Jun 2023)
Cisplatin ototoxicity mechanism and antagonistic intervention strategy: a scope review
- Yingru Li,
- Yingru Li,
- Yingru Li,
- Tianyang Zhang,
- Tianyang Zhang,
- Tianyang Zhang,
- Qiang Song,
- Qiang Song,
- Qiang Song,
- Dekun Gao,
- Dekun Gao,
- Dekun Gao,
- Yue Li,
- Yue Li,
- Yue Li,
- Huiqun Jie,
- Huiqun Jie,
- Huiqun Jie,
- Ping Huang,
- Ping Huang,
- Ping Huang,
- Guiliang Zheng,
- Guiliang Zheng,
- Guiliang Zheng,
- Jun Yang,
- Jun Yang,
- Jun Yang,
- Jingchun He,
- Jingchun He,
- Jingchun He
Affiliations
- Yingru Li
- Department of Otorhinolaryngology–Head and Neck Surgery, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China
- Yingru Li
- School of Medicine, Ear Institute, Shanghai Jiao Tong University, Shanghai, China
- Yingru Li
- Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Tianyang Zhang
- Department of Otorhinolaryngology–Head and Neck Surgery, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China
- Tianyang Zhang
- School of Medicine, Ear Institute, Shanghai Jiao Tong University, Shanghai, China
- Tianyang Zhang
- Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Qiang Song
- Department of Otorhinolaryngology–Head and Neck Surgery, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China
- Qiang Song
- School of Medicine, Ear Institute, Shanghai Jiao Tong University, Shanghai, China
- Qiang Song
- Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Dekun Gao
- Department of Otorhinolaryngology–Head and Neck Surgery, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China
- Dekun Gao
- School of Medicine, Ear Institute, Shanghai Jiao Tong University, Shanghai, China
- Dekun Gao
- Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Yue Li
- Department of Otorhinolaryngology–Head and Neck Surgery, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China
- Yue Li
- School of Medicine, Ear Institute, Shanghai Jiao Tong University, Shanghai, China
- Yue Li
- Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Huiqun Jie
- Department of Otorhinolaryngology–Head and Neck Surgery, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China
- Huiqun Jie
- School of Medicine, Ear Institute, Shanghai Jiao Tong University, Shanghai, China
- Huiqun Jie
- Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Ping Huang
- Department of Otorhinolaryngology–Head and Neck Surgery, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China
- Ping Huang
- School of Medicine, Ear Institute, Shanghai Jiao Tong University, Shanghai, China
- Ping Huang
- Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Guiliang Zheng
- Department of Otorhinolaryngology–Head and Neck Surgery, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China
- Guiliang Zheng
- School of Medicine, Ear Institute, Shanghai Jiao Tong University, Shanghai, China
- Guiliang Zheng
- Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Jun Yang
- Department of Otorhinolaryngology–Head and Neck Surgery, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China
- Jun Yang
- School of Medicine, Ear Institute, Shanghai Jiao Tong University, Shanghai, China
- Jun Yang
- Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Jingchun He
- Department of Otorhinolaryngology–Head and Neck Surgery, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China
- Jingchun He
- School of Medicine, Ear Institute, Shanghai Jiao Tong University, Shanghai, China
- Jingchun He
- Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- DOI
- https://doi.org/10.3389/fncel.2023.1197051
- Journal volume & issue
-
Vol. 17
Abstract
Cisplatin is a first-line chemotherapeutic agent in the treatment of malignant tumors with remarkable clinical effects and low cost. However, the ototoxicity and neurotoxicity of cisplatin greatly limit its clinical application. This article reviews the possible pathways and molecular mechanisms of cisplatin trafficking from peripheral blood into the inner ear, the toxic response of cisplatin to inner ear cells, as well as the cascade reactions leading to cell death. Moreover, this article highlights the latest research progress in cisplatin resistance mechanism and cisplatin ototoxicity. Two effective protective mechanisms, anti-apoptosis and mitophagy activation, and their interaction in the inner ear are discussed. Additionally, the current clinical preventive measures and novel therapeutic agents for cisplatin ototoxicity are described. Finally, this article also forecasts the prospect of possible drug targets for mitigating cisplatin-induced ototoxicity. These include the use of antioxidants, inhibitors of transporter proteins, inhibitors of cellular pathways, combination drug delivery methods, and other mechanisms that have shown promise in preclinical studies. Further research is needed to evaluate the efficacy and safety of these approaches.
Keywords
