Nature Communications (Nov 2021)

The NUCKS1-SKP2-p21/p27 axis controls S phase entry

  • Samuel Hume,
  • Claudia P. Grou,
  • Pauline Lascaux,
  • Vincenzo D’Angiolella,
  • Arnaud J. Legrand,
  • Kristijan Ramadan,
  • Grigory L. Dianov

DOI
https://doi.org/10.1038/s41467-021-27124-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Entry into S phase of the cell cycle is regulated positively by mitogens and negatively by DNA damage; however, how balance of these signals is achieved is not well known. Here the authors show that the NUCKS1-SKP2- p21/p27 axis integrates this information, where the NUCKS1 transcription factor affects levels of p21/p27 to readout the mitogen:DNA damage balance and regulate S phase entry decision.