mBio
(Jun 2021)
A Structural Model for the Ligand Binding of Pneumococcal Serotype 3 Capsular Polysaccharide-Specific Protective Antibodies
Ahmet Ozdilek,
Jiachen Huang,
Rachelle Babb,
Amy V. Paschall,
Dustin R. Middleton,
Jeremy A. Duke,
Liise-anne Pirofski,
Jarrod J. Mousa,
Fikri Y. Avci
Affiliations
Ahmet Ozdilek
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA
Jiachen Huang
Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA
Rachelle Babb
Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA
Amy V. Paschall
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA
Dustin R. Middleton
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA
Jeremy A. Duke
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA
Liise-anne Pirofski
Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA
Jarrod J. Mousa
ORCiD Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA
Fikri Y. Avci
ORCiD Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA
DOI
https://doi.org/10.1128/mBio.00800-21
Journal volume & issue
Vol. 12,
no. 3
Abstract
Read online
Infectious diseases caused by pathogenic bacteria are a major threat to human health. Capsular polysaccharides (CPSs) of many pathogenic bacteria have been used as the main components of glycoconjugate vaccines against bacterial diseases in clinical practice worldwide, with various degrees of success.
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