Journal of Pharmacological Sciences (Jan 2003)

Augmentation of the Delayed Rectifier Potassium Current by ETA Endothelin Receptor in Guinea Pig Atrial Myocytes

  • Kageyoshi Ono

DOI
https://doi.org/10.1254/s1347-8613(19)32778-1
Journal volume & issue
Vol. 91, no. 1
pp. 79 – 82

Abstract

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The role of ETA endothelin receptor (ETAR) in the regulation of the delayed rectifier potassium current (IK) was examined in guinea pig atrial myocytes. Application of ET-1 (10 nM) together with an ETB-receptor-selective antagonist, BQ-788 (300 nM), significantly increased the voltage-dependent activation of IK without affecting its half-activation voltage or the slope factor, while it suppressed the calcium current (ICaL) and displaced the time-independent background current to the outward direction. The data suggests that the augmentation of IK contributes to the ETA-receptor-mediated shortening of action potential duration, and hence to the negative inotropic response, in atria.