Nature Communications (Jul 2021)
Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer
- Li-Yan Li,
- Qian Yang,
- Yan-Yi Jiang,
- Wei Yang,
- Yuan Jiang,
- Xiang Li,
- Masaharu Hazawa,
- Bo Zhou,
- Guo-Wei Huang,
- Xiu-E Xu,
- Sigal Gery,
- Ying Zhang,
- Ling-Wen Ding,
- Allen S. Ho,
- Zachary S. Zumsteg,
- Ming-Rong Wang,
- Melissa J. Fullwood,
- Stephen J. Freedland,
- Stephen J. Meltzer,
- Li-Yan Xu,
- En-Min Li,
- H. Phillip Koeffler,
- De-Chen Lin
Affiliations
- Li-Yan Li
- The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College
- Qian Yang
- Department of Medicine, Samuel Oschin Cancer Center, Cedars-Sinai Medical Center
- Yan-Yi Jiang
- Department of Medicine, Samuel Oschin Cancer Center, Cedars-Sinai Medical Center
- Wei Yang
- Departments of Surgery and Biomedical Sciences, Cedars-Sinai Medical Center
- Yuan Jiang
- Department of Medicine, Samuel Oschin Cancer Center, Cedars-Sinai Medical Center
- Xiang Li
- The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College
- Masaharu Hazawa
- Cell-Bionomics Research Unit, Innovative Integrated Bio-Research Core, Institute for Frontier Science Initiative, Kanazawa University
- Bo Zhou
- Departments of Surgery and Biomedical Sciences, Cedars-Sinai Medical Center
- Guo-Wei Huang
- Department of Medicine, Samuel Oschin Cancer Center, Cedars-Sinai Medical Center
- Xiu-E Xu
- The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College
- Sigal Gery
- Department of Medicine, Samuel Oschin Cancer Center, Cedars-Sinai Medical Center
- Ying Zhang
- Cancer Science Institute of Singapore, National University of Singapore
- Ling-Wen Ding
- Cancer Science Institute of Singapore, National University of Singapore
- Allen S. Ho
- Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, Samuel Oschin Cancer Center, Cedars-Sinai Medical Center
- Zachary S. Zumsteg
- Department of Radiation Oncology, Cedars-Sinai Medical Center
- Ming-Rong Wang
- State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Melissa J. Fullwood
- Cancer Science Institute of Singapore, National University of Singapore
- Stephen J. Freedland
- Division of Urology, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, USA and the Durham VA Medical Center
- Stephen J. Meltzer
- Departments of Medicine and Oncology, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center
- Li-Yan Xu
- The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College
- En-Min Li
- The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College
- H. Phillip Koeffler
- Department of Medicine, Samuel Oschin Cancer Center, Cedars-Sinai Medical Center
- De-Chen Lin
- Department of Medicine, Samuel Oschin Cancer Center, Cedars-Sinai Medical Center
- DOI
- https://doi.org/10.1038/s41467-021-24656-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
The relevance and underlying molecular mechanisms of epigenetic regulation in squamous cell carcinomas (SCC) await further characterization. Here, the authors show a transcriptional regulatory loop involving SREBF1, TP63 and KLF5 driving tumourigenesis in SCC through fatty acid, ERBB and mTOR pathway regulation.
