Nature Communications (Aug 2020)
The genetic architecture of human brainstem structures and their involvement in common brain disorders
- Torbjørn Elvsåshagen,
- Shahram Bahrami,
- Dennis van der Meer,
- Ingrid Agartz,
- Dag Alnæs,
- Deanna M. Barch,
- Ramona Baur-Streubel,
- Alessandro Bertolino,
- Mona K. Beyer,
- Giuseppe Blasi,
- Stefan Borgwardt,
- Birgitte Boye,
- Jan Buitelaar,
- Erlend Bøen,
- Elisabeth Gulowsen Celius,
- Simon Cervenka,
- Annette Conzelmann,
- David Coynel,
- Pasquale Di Carlo,
- Srdjan Djurovic,
- Sarah Eisenacher,
- Thomas Espeseth,
- Helena Fatouros-Bergman,
- Lena Flyckt,
- Barbara Franke,
- Oleksandr Frei,
- Barbara Gelao,
- Hanne Flinstad Harbo,
- Catharina A. Hartman,
- Asta Håberg,
- Dirk Heslenfeld,
- Pieter J. Hoekstra,
- Einar A. Høgestøl,
- Rune Jonassen,
- Erik G. Jönsson,
- Karolinska Schizophrenia Project (KaSP) consortium,
- Peter Kirsch,
- Iwona Kłoszewska,
- Trine Vik Lagerberg,
- Nils Inge Landrø,
- Stephanie Le Hellard,
- Klaus-Peter Lesch,
- Luigi A. Maglanoc,
- Ulrik F. Malt,
- Patrizia Mecocci,
- Ingrid Melle,
- Andreas Meyer-Lindenberg,
- Torgeir Moberget,
- Jan Egil Nordvik,
- Lars Nyberg,
- Kevin S. O’ Connell,
- Jaap Oosterlaan,
- Marco Papalino,
- Andreas Papassotiropoulos,
- Paul Pauli,
- Giulio Pergola,
- Karin Persson,
- Dominique de Quervain,
- Andreas Reif,
- Jaroslav Rokicki,
- Daan van Rooij,
- Alexey A. Shadrin,
- André Schmidt,
- Emanuel Schwarz,
- Geir Selbæk,
- Hilkka Soininen,
- Piotr Sowa,
- Vidar M. Steen,
- Magda Tsolaki,
- Bruno Vellas,
- Lei Wang,
- Eric Westman,
- Georg C. Ziegler,
- Mathias Zink,
- Ole A. Andreassen,
- Lars T. Westlye,
- Tobias Kaufmann
Affiliations
- Torbjørn Elvsåshagen
- NORMENT, Division of Mental Health and Addiction, Oslo University Hospital
- Shahram Bahrami
- NORMENT, Division of Mental Health and Addiction, Oslo University Hospital
- Dennis van der Meer
- NORMENT, Division of Mental Health and Addiction, Oslo University Hospital
- Ingrid Agartz
- Department of Psychiatric Research, Diakonhjemmet Hospital
- Dag Alnæs
- NORMENT, Division of Mental Health and Addiction, Oslo University Hospital
- Deanna M. Barch
- Departments of Psychological & Brain Sciences, Psychiatry, and Radiology, Washington University in St. Louis
- Ramona Baur-Streubel
- Department of Psychology I and Centre of Mental Health, University of Würzburg
- Alessandro Bertolino
- Institute of Psychiatry, University of Bari
- Mona K. Beyer
- Institute of Clinical Medicine, University of Oslo
- Giuseppe Blasi
- Institute of Psychiatry, University of Bari
- Stefan Borgwardt
- Department of Psychiatry (UPK), University of Basel
- Birgitte Boye
- Psychosomatic and CL Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital
- Jan Buitelaar
- Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center
- Erlend Bøen
- Psychosomatic and CL Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital
- Elisabeth Gulowsen Celius
- Department of Neurology, Division of Clinical Neuroscience, Oslo University Hospital
- Simon Cervenka
- Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region
- Annette Conzelmann
- Children and Adolescence Psychiatry, University of Tübingen
- David Coynel
- Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
- Pasquale Di Carlo
- Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro
- Srdjan Djurovic
- Department of Medical Genetics, Oslo University Hospital
- Sarah Eisenacher
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Thomas Espeseth
- Department of Psychology, University of Oslo
- Helena Fatouros-Bergman
- Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region
- Lena Flyckt
- Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region
- Barbara Franke
- Departments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center
- Oleksandr Frei
- NORMENT, Division of Mental Health and Addiction, Oslo University Hospital
- Barbara Gelao
- Institute of Psychiatry, University of Bari
- Hanne Flinstad Harbo
- Department of Neurology, Division of Clinical Neuroscience, Oslo University Hospital
- Catharina A. Hartman
- Department of Psychiatry, University of Groningen, University Medical Center Groningen
- Asta Håberg
- Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology
- Dirk Heslenfeld
- Clinical Neuropsychology section, Vrije Universiteit Amsterdam
- Pieter J. Hoekstra
- Department of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen
- Einar A. Høgestøl
- Department of Neurology, Division of Clinical Neuroscience, Oslo University Hospital
- Rune Jonassen
- Department of Psychology, University of Oslo
- Erik G. Jönsson
- NORMENT, Division of Mental Health and Addiction, Oslo University Hospital
- Karolinska Schizophrenia Project (KaSP) consortium
- Peter Kirsch
- Department of Clinical Psychology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Iwona Kłoszewska
- Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz
- Trine Vik Lagerberg
- NORMENT, Division of Mental Health and Addiction, Oslo University Hospital
- Nils Inge Landrø
- Department of Psychiatric Research, Diakonhjemmet Hospital
- Stephanie Le Hellard
- NORMENT, Department of Clinical Science, University of Bergen
- Klaus-Peter Lesch
- Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg
- Luigi A. Maglanoc
- NORMENT, Division of Mental Health and Addiction, Oslo University Hospital
- Ulrik F. Malt
- Institute of Clinical Medicine, University of Oslo
- Patrizia Mecocci
- Institute of Gerontology and Geriatrics, University of Perugia
- Ingrid Melle
- NORMENT, Division of Mental Health and Addiction, Oslo University Hospital
- Andreas Meyer-Lindenberg
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Torgeir Moberget
- NORMENT, Division of Mental Health and Addiction, Oslo University Hospital
- Jan Egil Nordvik
- The CatoSenteret Rehabilitation Center
- Lars Nyberg
- Departments of Radiation Sciences and Integrative Medical Biology, Umeå Center for Functional Brain Imaging, Umeå University
- Kevin S. O’ Connell
- NORMENT, Division of Mental Health and Addiction, Oslo University Hospital
- Jaap Oosterlaan
- Clinical Neuropsychology section, Vrije Universiteit Amsterdam
- Marco Papalino
- Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro
- Andreas Papassotiropoulos
- Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
- Paul Pauli
- Department of Psychology I and Centre of Mental Health, University of Würzburg
- Giulio Pergola
- Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro
- Karin Persson
- Department of Geriatric Medicine, Oslo University Hospital
- Dominique de Quervain
- Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
- Andreas Reif
- Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt
- Jaroslav Rokicki
- NORMENT, Division of Mental Health and Addiction, Oslo University Hospital
- Daan van Rooij
- Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center
- Alexey A. Shadrin
- NORMENT, Division of Mental Health and Addiction, Oslo University Hospital
- André Schmidt
- Department of Psychiatry (UPK), University of Basel
- Emanuel Schwarz
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Geir Selbæk
- Institute of Clinical Medicine, University of Oslo
- Hilkka Soininen
- Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland
- Piotr Sowa
- Division of Radiology and Nuclear Medicine, Oslo University Hospital
- Vidar M. Steen
- NORMENT, Department of Clinical Science, University of Bergen
- Magda Tsolaki
- 1st University Department of Neurology, Aristotle University of Thessaloniki
- Bruno Vellas
- INSERM U 1027, University of Toulouse
- Lei Wang
- Feinberg School of Medicine, Northwestern University
- Eric Westman
- Institute of Psychiatry, King’s College
- Georg C. Ziegler
- Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg
- Mathias Zink
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Ole A. Andreassen
- NORMENT, Division of Mental Health and Addiction, Oslo University Hospital
- Lars T. Westlye
- NORMENT, Division of Mental Health and Addiction, Oslo University Hospital
- Tobias Kaufmann
- NORMENT, Division of Mental Health and Addiction, Oslo University Hospital
- DOI
- https://doi.org/10.1038/s41467-020-17376-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
The genetic architecture underlying brainstem regions and how this links to common brain disorders is not well understood. Here, the authors use MRI and GWAS data from 27,034 individuals to identify genetic and morphological brainstem features that influence common brain disorders.
