Exposure to triphenyltin impairs gut integrity, disturbs gut microbiota, and alters fecal metabolites

Xiuxiu Chen; Donghui Zhu; Fan Zhang; Ouyang Li; Fan Yang; Zhijun Bao

Ecotoxicology and Environmental Safety (Jan 2024)

Exposure to triphenyltin impairs gut integrity, disturbs gut microbiota, and alters fecal metabolites

Xiuxiu Chen,
Donghui Zhu,
Fan Zhang,
Ouyang Li,
Fan Yang,
Zhijun Bao

Affiliations

Xiuxiu Chen: Department of Gerontology, Huadong Hospital Affiliated to Fudan University, Shanghai, China; Research Center on Aging and Medicine, Fudan University, Shanghai, China; Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, China, Fudan University, Shanghai, China
Donghui Zhu: The Department of Cardiovascular and Thoracic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China
Fan Zhang: Department of Gerontology, Huadong Hospital Affiliated to Fudan University, Shanghai, China; Research Center on Aging and Medicine, Fudan University, Shanghai, China; Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, China, Fudan University, Shanghai, China
Ouyang Li: Department of Gerontology, Huadong Hospital Affiliated to Fudan University, Shanghai, China; Research Center on Aging and Medicine, Fudan University, Shanghai, China; Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, China, Fudan University, Shanghai, China
Fan Yang: Department of Gerontology, Huadong Hospital Affiliated to Fudan University, Shanghai, China; Research Center on Aging and Medicine, Fudan University, Shanghai, China; Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, China, Fudan University, Shanghai, China; Corresponding authors at: Department of Gerontology, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
Zhijun Bao: Department of Gerontology, Huadong Hospital Affiliated to Fudan University, Shanghai, China; Research Center on Aging and Medicine, Fudan University, Shanghai, China; Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, China, Fudan University, Shanghai, China; Corresponding authors at: Department of Gerontology, Huadong Hospital Affiliated to Fudan University, Shanghai, China.

Journal volume & issue: Vol. 269
p. 115753

Abstract

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Triphenyltin is an environmental contaminant widely used in antifouling paints and can cause toxicity in various organs in living organisms. However, its effects on intestinal function and the microbiome of the gut remain unknown. The objective of this study was to explore the intestinal toxicity of triphenyltin in mice by orally administering 0, 1.875, 3.75, and 7.5 mg/Kg to adult male mice for 8 weeks. Results showed that triphenyltin caused ileum tissue damage, induced oxidative stress, upregulated inflammation-related gene expression and increased serum tumor-necrosis factor α (TNF-α) levels in mice. Triphenyltin impaired ileum barrier function by downregulating Muc2, ZO-1, Occludin and their protein levels at 3.75 and 7.5 mg/Kg. TPT exposure led to partial inflammation and decreased mucin mRNA expression in the colon. Triphenyltin altered intestinal micro-ecological balance and fecal metabolome in mice. In conclusion, triphenyltin alters the mouse gut microbiota and fecal metabolome.

Published in Ecotoxicology and Environmental Safety

ISSN: 0147-6513 (Print); 1090-2414 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Technology: Environmental technology. Sanitary engineering: Environmental pollution; Geography. Anthropology. Recreation: Environmental sciences
Website: https://www.journals.elsevier.com/ecotoxicology-and-environmental-safety

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