Nature Communications (Jan 2021)
Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex
- Kamran Rizzolo,
- Angela Yeou Hsiung Yu,
- Adedeji Ologbenla,
- Sa-Rang Kim,
- Haojie Zhu,
- Koichiro Ishimori,
- Guillaume Thibault,
- Elisa Leung,
- Yi Wen Zhang,
- Mona Teng,
- Marta Haniszewski,
- Noha Miah,
- Sadhna Phanse,
- Zoran Minic,
- Sukyeong Lee,
- Julio Diaz Caballero,
- Mohan Babu,
- Francis T. F. Tsai,
- Tomohide Saio,
- Walid A. Houry
Affiliations
- Kamran Rizzolo
- Department of Biochemistry, University of Toronto
- Angela Yeou Hsiung Yu
- Department of Biochemistry, University of Toronto
- Adedeji Ologbenla
- Department of Biochemistry, University of Toronto
- Sa-Rang Kim
- Department of Biochemistry, University of Toronto
- Haojie Zhu
- Graduate School of Chemical Sciences and Engineering, Hokkaido University
- Koichiro Ishimori
- Graduate School of Chemical Sciences and Engineering, Hokkaido University
- Guillaume Thibault
- Department of Biochemistry, University of Toronto
- Elisa Leung
- Department of Biochemistry, University of Toronto
- Yi Wen Zhang
- Department of Biochemistry, University of Toronto
- Mona Teng
- Department of Biochemistry, University of Toronto
- Marta Haniszewski
- Department of Biochemistry, University of Toronto
- Noha Miah
- Department of Biochemistry, University of Toronto
- Sadhna Phanse
- Department of Biochemistry, University of Toronto
- Zoran Minic
- Department of Biochemistry, University of Regina
- Sukyeong Lee
- Department of Biochemistry and Molecular Biology, Baylor College of Medicine
- Julio Diaz Caballero
- Department of Cell and Systems Biology, University of Toronto
- Mohan Babu
- Department of Biochemistry, University of Regina
- Francis T. F. Tsai
- Department of Biochemistry and Molecular Biology, Baylor College of Medicine
- Tomohide Saio
- Institute of Advanced Medical Sciences, Tokushima University
- Walid A. Houry
- Department of Biochemistry, University of Toronto
- DOI
- https://doi.org/10.1038/s41467-020-20553-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
ClpXP is the main ATP-dependent proteolytic complex in bacteria, is essential for maintaining cellular protein homeostasis and is also critical for bacterial pathogenesis. Here, the authors establish a functional link between ClpXP and trigger actor, a chaperone involved in the early stages of protein folding.
