INTERCHANGEABILITY OF MYOCARDIAL CYTOPROTECTORS IN PATIENTS WITH ISCHEMIC HEART DISEASE. DIFFICULT QUESTIONS –SIMPLE SOLUTIONS

Abstract

Indications for myocardial cytoprotector, trimetazidine, in patients with ischemic heart disease are analyzed and justified according to evidence based medicine. Results of a multicenter randomized comparative KARDIOKANON study are discussed in terms of efficacy and tolerability of two variants of the complex 12-week treatment in patients with angina II-III functional class, based on the original and generic drugs. The study showed clinical equivalence of the generic DeprenormR (Canonpharma Production) to the original trimetazidine.

Keywords

• ишемическая болезнь сердца
• хроническая сердечная недостаточность
• стенокардия
• прекондиционирование
• цитопротекция
• триметазидин
• оригинальный препарат
• дженерик
• фармакотерапия