The Role of the Histone Methyltransferase PfSET10 in Antigenic Variation by Malaria Parasites: a Cautionary Tale

Che J. Ngwa; Mackensie R. Gross; Jean-Pierre Musabyimana; Gabriele Pradel; Kirk W. Deitsch

doi:10.1128/mSphere.01217-20

mSphere (Feb 2021)

The Role of the Histone Methyltransferase PfSET10 in Antigenic Variation by Malaria Parasites: a Cautionary Tale

Che J. Ngwa,
Mackensie R. Gross,
Jean-Pierre Musabyimana,
Gabriele Pradel,
Kirk W. Deitsch

Affiliations

Che J. Ngwa: Division of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, Aachen, Germany
Mackensie R. Gross: Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA
Jean-Pierre Musabyimana: Division of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, Aachen, Germany
Gabriele Pradel: Division of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, Aachen, Germany
Kirk W. Deitsch: ORCiD; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA

DOI: https://doi.org/10.1128/mSphere.01217-20
Journal volume & issue: Vol. 6, no. 1

Abstract

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The identification of specific epigenetic regulatory proteins in infectious organisms has become a high-profile research topic and a focus for several drug development initiatives. However, studies that define specific roles for different epigenetic modifiers occasionally report differing results, and we similarly provide evidence regarding the histone methyltransferase PfSET10 that is in stark contrast with previously published results.

Published in mSphere

ISSN: 2379-5042 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msphere

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