Dynamic enlargement and mobilization of lipid droplets in pluripotent cells coordinate morphogenesis during mouse peri-implantation development

King Hang Tommy Mau; Donja Karimlou; David Barneda; Vincent Brochard; Christophe Royer; Bryony Leeke; Roshni A. de Souza; Mélanie Pailles; Michelle Percharde; Shankar Srinivas; Alice Jouneau; Mark Christian; Véronique Azuara

doi:10.1038/s41467-022-31323-2

Nature Communications (Jul 2022)

Dynamic enlargement and mobilization of lipid droplets in pluripotent cells coordinate morphogenesis during mouse peri-implantation development

King Hang Tommy Mau,
Donja Karimlou,
David Barneda,
Vincent Brochard,
Christophe Royer,
Bryony Leeke,
Roshni A. de Souza,
Mélanie Pailles,
Michelle Percharde,
Shankar Srinivas,
Alice Jouneau,
Mark Christian,
Véronique Azuara

Affiliations

King Hang Tommy Mau: Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, Hammersmith Hospital
Donja Karimlou: Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, Hammersmith Hospital
David Barneda: Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, Hammersmith Hospital
Vincent Brochard: Université Paris-Saclay, UVSQ, INRAE, BREED
Christophe Royer: Institute of Developmental & Regenerative Medicine, Department of Physiology, Anatomy and Genetics, University of Oxford
Bryony Leeke: MRC London Institute of Medical Sciences (LMS), Hammersmith Hospital
Roshni A. de Souza: Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, Hammersmith Hospital
Mélanie Pailles: Université Paris-Saclay, UVSQ, INRAE, BREED
Michelle Percharde: Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, Hammersmith Hospital
Shankar Srinivas: Institute of Developmental & Regenerative Medicine, Department of Physiology, Anatomy and Genetics, University of Oxford
Alice Jouneau: Université Paris-Saclay, UVSQ, INRAE, BREED
Mark Christian: Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, Hammersmith Hospital
Véronique Azuara: Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, Hammersmith Hospital

DOI: https://doi.org/10.1038/s41467-022-31323-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Prior to its implantation into the uterus, the mammalian embryo stores substantial lipids. Here the authors unveil how lipid storage and morphogenesis of pluripotent stem cells are fundamentally connected during peri-implantation development.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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