Topical Dudesonide Rnse for Postoperative Care in Chronic Rhino-Sinusitis with and without Polyp

Abstract

Background and objectives: Chronic rhino sinusitis is a chronic inflammatory disease of the nasal mucosa and paranasal sinuses with no complete symptom resolution. The present study aimed to evaluate the efficacy of budesoniderinse on patients with chronic rhino sinusitis with and without a polyp. Methods: A total of 50 patients underwent operation for chronic rhino sinusitis, with or without nasal polyps were randomly assigned into experimental (25 patients) and control groups (25 patients). The patients in the experimental group received 2 cc of budesonide 0.5mg mixed with 240 cc of normal saline, used 2 times daily 50 cc (50 cc equals 0.2 mg budesonide) for each nostril for three months, whereas, the patients in control group received only normal saline. The efficacy of budesonide solution irrigation was assessed by SNOT 22. Results: The mean scores of SNOT-22 in both groups were significantly improved compared to baseline. Whereas, the improvement between experimental (26.0, 33.48, and 39.36 for 1, 2, and 3 months, respectively) and control groups (25.92, 29.88, and 34.32 for 1, 2, and 3 months, respectively) were not significant statistically. The patients with Chronic rhino sinusitis and without polyp in the experimental groups showed the significantly lower SNOT-22 scores for month 2 (27.13 vs. 36.47) and month 3 (33.25 vs. 42.24) compared to the patients with a polyp. Conclusions: The study showed that both methods of post-operative nasal irrigation with normal saline alone or budesonide mixed with normal saline had significant improvement in the scores of SNOT-22. However, the difference between the two methods was not statistically significant.

Keywords

• Budesonide
• Rhino sinusitis
• Sinusitis