DYNAMICS OF CYTOKINE LEVELS IN PATIENTS WITH MYOCARDIAL INFARCTION AFTER URGENT PERCUTANEOUS CORONARY INTERVENTION

Abstract

Abstract. The study included 154 cases of acute myocardial infarction (MI) with ST segment elevation. Cytokine levels were determined in all the patients at days +1 and +10 after hospital admission, using quantitative ELISA assays. On day +1, a more that 2-fold increase was revealed for TNFα and IL-1α, as compared with healthy individuals. On day +10, we found a more than twofold increase in TNFα and IL-8 in blood plasma, whereas IL-1α and IL-10 levels became significantly reduced by the day +10, as compared to median values at day +1 of the study. Moreover, dynamics of the cytokines was compared between clinical subgroups of MI patients classified by gender, age, or presence of early complications. It was noted that the patients with complicated course of myocardial infarction exhibited high levels of IL-1α both on the day 1, and on day +10 of the disease. In female patients, the levels of both IL-8 and IL-10 were not significantly changed by day +10 after MI. Among younger patients (<56 years old), a significant reduction of IL-10 plasma levels was shown by day +10 of myocardial infarction, as compared with absence of significant IL-10 dynamics in older patients.

Keywords

• cytokines
• myocardial infarction
• nonspecific inflammation
• biomarkers