Efficacy of Mucuna pruriens (L.) DC. in treating diabetes, Parkinson’s disease, and erectile dysfunction—a review of clinical and preclinical trials

Abstract

Among the most common medical problems experienced by older adults (over 60 years) are diabetes, Parkinson’s disease (PD), and erectile dysfunction (ED). The potential use of Mucuna pruriens in treating type 2 diabetes (T2D), PD, and ED is being investigated. Literature searches were conducted using the PubMed, MEDLINE, and Mendeley databases (1990–2023). Key words related to Mucuna pruriens, PD, diabetes, and EDs were used. An analysis of 26 preclinical and clinical trials suggested that Mucuna pruriens may be used to treat PD, diabetes, and ED. This study revealed a correlation between diabetes, Parkinson’s, and ED, with metabolic disorders being the common cause. Mucuna pruriens-based therapeutics could be a positive source of leva-dopa (LD) medications. It is well tolerated and beneficial for brain function and overall health. Evidence suggests that it has positive effects on libido, testosterone levels, and PD. It is important to note that PD and ED are linked by multiple mechanisms. In many clinical trials (in humans and animals), Mucuna pruriens were found to be effective at treating ED, PD, and diabetes. It is further necessary to conduct additional scientific studies to confirm the molecular mechanisms and biomarkers that link Mucuna pruriens phytochemicals with PD, ED, and diabetes.

Keywords

• erectile dysfunction
• mucuna pruriens
• metabolic disorders
• mitochondria
• parkinson’s disease