Nature Communications (Sep 2019)
B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma
- Johannes Griss,
- Wolfgang Bauer,
- Christine Wagner,
- Martin Simon,
- Minyi Chen,
- Katharina Grabmeier-Pfistershammer,
- Margarita Maurer-Granofszky,
- Florian Roka,
- Thomas Penz,
- Christoph Bock,
- Gao Zhang,
- Meenhard Herlyn,
- Katharina Glatz,
- Heinz Läubli,
- Kirsten D. Mertz,
- Peter Petzelbauer,
- Thomas Wiesner,
- Markus Hartl,
- Winfried F. Pickl,
- Rajasekharan Somasundaram,
- Peter Steinberger,
- Stephan N. Wagner
Affiliations
- Johannes Griss
- Department of Dermatology, Medical University of Vienna
- Wolfgang Bauer
- Department of Dermatology, Medical University of Vienna
- Christine Wagner
- Department of Dermatology, Medical University of Vienna
- Martin Simon
- Department of Dermatology, Medical University of Vienna
- Minyi Chen
- Department of Dermatology, Medical University of Vienna
- Katharina Grabmeier-Pfistershammer
- Department of Dermatology, Medical University of Vienna
- Margarita Maurer-Granofszky
- Department of Dermatology, Medical University of Vienna
- Florian Roka
- Department of Dermatology, Medical University of Vienna
- Thomas Penz
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Christoph Bock
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Gao Zhang
- Molecular & Cellular Oncogenesis Program and Melanoma Research Center, The Wistar Institute
- Meenhard Herlyn
- Molecular & Cellular Oncogenesis Program and Melanoma Research Center, The Wistar Institute
- Katharina Glatz
- Institute of Pathology, University Hospital Basel
- Heinz Läubli
- Division of Medical Oncology, University Hospital Basel
- Kirsten D. Mertz
- Institute of Pathology, Cantonal Hospital Baselland
- Peter Petzelbauer
- Department of Dermatology, Medical University of Vienna
- Thomas Wiesner
- Department of Dermatology, Medical University of Vienna
- Markus Hartl
- Mass Spectrometry Facility, Max F. Perutz Laboratories (MFPL), University of Vienna, Vienna BioCenter (VBC)
- Winfried F. Pickl
- Division of Cellular Immunology and Immunohematology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna
- Rajasekharan Somasundaram
- Molecular & Cellular Oncogenesis Program and Melanoma Research Center, The Wistar Institute
- Peter Steinberger
- Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna
- Stephan N. Wagner
- Department of Dermatology, Medical University of Vienna
- DOI
- https://doi.org/10.1038/s41467-019-12160-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
The regulation of tumor inflammation is incompletely understood and the role of B cells is unclear. Here, the authors show that a specific subtype of B cells is induced in melanoma and required to recruit T lymphocytes and elicit inflammation.
