On system-spanning demixing properties of cell polarization.

Abstract

A number of mathematical models have been suggested to describe cell polarization in eukaryotic cells. One class of models takes into account that certain proteins are conserved on the time scale of cell polarization and may switch between a fast and a slow diffusing state. We raise the question whether models sharing this design feature can be condensed into one system-spanning model. We show exemplarily for the mass-conserved reaction-diffusion model of Otsuji et al. (Otsuji M et al. (2007) PLoS Comput Biol 3(6):e108) that cell polarization can be classified as active phase separation. This includes a fundamental connection between a number of non-equilibrium demixing phenomena such as cell polarization to phase separation. As shown recently, generic properties of active phase separation close to its onset are described by the Cahn-Hilliard model. By a systematic perturbation analysis we directly map the basic cell polarization model to the universal Cahn-Hilliard model. Comparing the numerical solutions of the polarization model and the Cahn-Hilliard equation also provides the parameter range where the basic cell polarization model behaves like other systems showing active phase separation. Polarization models of the active phase separation type cover essential properties of cell polarization, e.g. the adaptability of cell polarity to the length of growing cells. Our approach highlights how basic principles of pattern formation theory allow the identification of common basic properties in different models for cell polarization.