Vitamin D supplementation in patients with Hashimoto’s disease

Abstract

Introduction : Hashimoto’s thyroiditis (HT) is the most common autoimmune disease and the leading cause of hypothyroidism in the world. The condition results in damage to the thyroid gland, brought about by the infiltration of lymphocytes. For the majority of individuals with Hashimoto's thyroiditis, a lifelong requirement for levothyroxine substitution is required. The potential contribution of diet and supplements to the management of HT is frequently overlooked. Low vitamin D levels are said to play a significant role in occurrence and severity of autoimmune thyroiditis. Currently, there is a continuing discussion regarding the optimal plasma concentration of 25-hydroxyvitamin D necessary for preventing or treating autoimmune diseases. Aim of the study : The purpose of this literature review is to evaluate the influence of vitamin D supplementation on the course of Hashimoto’s thyroiditis in the light of most up to date research. Materials and methods. This article is a review of publications obtained from the PubMed database, published between 2017-2023, based on the keywords "Hashimoto thyroiditis" "vitamin D" and "autoimmune thyroid disease". Conclusions. The correlation of vitamin D supplementation and Hashimoto’s disease still remains unclear due to conflicting results from numerous studies. Further research is necessary to accurately determine the effect of vitamin D supplementation on Hashimoto’s thyroiditis.

Keywords

• Hashimoto’s thyroiditis
• autoimmune thyroid disease
• vitamin D