Nature Communications (Mar 2020)

GenomeScope 2.0 and Smudgeplot for reference-free profiling of polyploid genomes

  • T. Rhyker Ranallo-Benavidez,
  • Kamil S. Jaron,
  • Michael C. Schatz

DOI
https://doi.org/10.1038/s41467-020-14998-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

Read online

Prior to genome assembly, the raw sequencing reads must be analyzed for assessment of major genome characteristics such as genome size, heterozygosity, and repetitiveness. For this purpose, the authors introduce GenomeScope 2.0, an extension of GenomeScope for polyploid genomes, and Smudgeplot, which can estimate a genome’s ploidy.