Frontiers in Immunology (Jan 2022)

SARS-CoV-2 Infection Triggers Auto-Immune Response in ARDS

  • Pablo Juanes-Velasco,
  • Alicia Landeira-Viñuela,
  • Marina L. García-Vaquero,
  • Quentin Lecrevisse,
  • Raquel Herrero,
  • Raquel Herrero,
  • Raquel Herrero,
  • Antonio Ferruelo,
  • Rafael Góngora,
  • Fernando Corrales,
  • Fernando Corrales,
  • Javier De Las Rivas,
  • Jose A. Lorente,
  • Jose A. Lorente,
  • Jose A. Lorente,
  • Jose A. Lorente,
  • Ángela-Patricia Hernández,
  • Manuel Fuentes,
  • Manuel Fuentes,
  • Manuel Fuentes

DOI
https://doi.org/10.3389/fimmu.2022.732197
Journal volume & issue
Vol. 13

Abstract

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Acute respiratory distress syndrome (ARDS) is a severe pulmonary disease, which is one of the major complications in COVID-19 patients. Dysregulation of the immune system and imbalances in cytokine release and immune cell activation are involved in SARS-CoV-2 infection. Here, the inflammatory, antigen, and auto-immune profile of patients presenting COVID-19-associated severe ARDS has been analyzed using functional proteomics approaches. Both, innate and humoral responses have been characterized through acute-phase protein network and auto-antibody signature. Severity and sepsis by SARS-CoV-2 emerged to be correlated with auto-immune profiles of patients and define their clinical progression, which could provide novel perspectives in therapeutics development and biomarkers of COVID-19 patients. Humoral response in COVID-19 patients’ profile separates with significant differences patients with or without ARDS. Furthermore, we found that this profile can be correlated with COVID-19 severity and results more common in elderly patients.

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