Immune response to vaccination in people with psychotic disorders relative to healthy controls: prospective study of SARS-CoV-2 vaccination
Oisín O'Brien,
Atheeshaan Arumuham,
Yuya Mizuno,
Luke Baxter,
Maria Lobo,
Sita Parmar,
Stephen Jolles,
Oliver D. Howes
Affiliations
Oisín O'Brien
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; South London and Maudsley NHS Foundation Trust, London, UK; and Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, UK
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; South London and Maudsley NHS Foundation Trust, London, UK; and Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, UK
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; South London and Maudsley NHS Foundation Trust, London, UK; and Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
Luke Baxter
South London and Maudsley NHS Foundation Trust, London, UK
Maria Lobo
South London and Maudsley NHS Foundation Trust, London, UK
Sita Parmar
South London and Maudsley NHS Foundation Trust, London, UK
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; South London and Maudsley NHS Foundation Trust, London, UK; and Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, UK
This prospective study examines the immune response to SARS-CoV-2 vaccination in patients with psychotic disorders compared with healthy volunteers. Participants were recruited naturalistically as part of the UK's COVID-19 vaccination programme. Prior to receiving their first COVID-19 vaccine, blood samples were provided by participants to examine anti-SARS-CoV-2 immunoglobulins (IgG) at baseline, followed by a repeat assay 1 month after receiving their first vaccine to assess vaccine response. The increase of IgG levels from baseline to 1 month post-vaccination was significantly lower in patients compared with controls, supporting evidence of impaired vaccine response in people with psychotic disorders. When excluding patients treated with clozapine from the analysis, this difference was no longer significant, suggesting that effects may be particularly marked in people taking clozapine.
