Development data associated with effects of stiffness softening of 3D-TIPS elastomer nanohybrid scaffolds on tissue ingrowth, vascularization and inflammation in vivo
Linxiao Wu,
Adrián Magaz,
Elizabeth Maughan,
Nina Oliver,
Arnold Darbyshire,
Marilena Loizidou,
Mark Emberton,
Martin Birchall,
Wenhui Song
Affiliations
Linxiao Wu
Centre for Biomaterials in Surgical Reconstruction and Regeneration, Division of Surgery & Interventional Science, University College London, London NW3 2PF, United Kingdom
Adrián Magaz
Centre for Biomaterials in Surgical Reconstruction and Regeneration, Division of Surgery & Interventional Science, University College London, London NW3 2PF, United Kingdom
Elizabeth Maughan
UCL Ear Institute, Royal National Throat Nose and Ear Hospital and University College London, London, United Kingdom
Nina Oliver
Centre for Biomaterials in Surgical Reconstruction and Regeneration, Division of Surgery & Interventional Science, University College London, London NW3 2PF, United Kingdom
Arnold Darbyshire
Centre for Biomaterials in Surgical Reconstruction and Regeneration, Division of Surgery & Interventional Science, University College London, London NW3 2PF, United Kingdom
Marilena Loizidou
Centre for Biomaterials in Surgical Reconstruction and Regeneration, Division of Surgery & Interventional Science, University College London, London NW3 2PF, United Kingdom
Mark Emberton
Centre for Biomaterials in Surgical Reconstruction and Regeneration, Division of Surgery & Interventional Science, University College London, London NW3 2PF, United Kingdom
Martin Birchall
UCL Ear Institute, Royal National Throat Nose and Ear Hospital and University College London, London, United Kingdom
Wenhui Song
Centre for Biomaterials in Surgical Reconstruction and Regeneration, Division of Surgery & Interventional Science, University College London, London NW3 2PF, United Kingdom; Corresponding author.
This DiB article contains data related to the research article entitled “Cellular responses to thermoresponsive stiffness memory elastomer nanohybrid scaffolds by 3D-TIPS” (Wu et al., 2018). Thermoresponsive poly (urea-urethane) nanohybrid elastomer (PUU-POSS) scaffolds were implanted in rats for up to 3 months. The porous structure and tensile mechanical properties of the scaffolds are listed and compared before and after in vitro and in vivo tests. The details of the histological analysis of the explants with different initial stiffness and porous structures at various time points are presented. The images and data presented support the conclusion about the coupled effects of stiffness softening and the hierarchical porous structure modulating tissue ingrowth, vascularization and macrophage polarization in the article (Wu et al., 2018).
