β-elemene regulates M1-M2 macrophage balance through the ERK/JNK/P38 MAPK signaling pathway

Yingyu Zhou; Tomohiro Takano; Xuyang Li; Yimei Wang; Rong Wang; Zhangliang Zhu; Masaru Tanokura; Takuya Miyakawa; Satoshi Hachimura

doi:10.1038/s42003-022-03369-x

Communications Biology (May 2022)

β-elemene regulates M1-M2 macrophage balance through the ERK/JNK/P38 MAPK signaling pathway

Yingyu Zhou,
Tomohiro Takano,
Xuyang Li,
Yimei Wang,
Rong Wang,
Zhangliang Zhu,
Masaru Tanokura,
Takuya Miyakawa,
Satoshi Hachimura

Affiliations

Yingyu Zhou: Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Tomohiro Takano: Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Xuyang Li: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Yimei Wang: Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Rong Wang: Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Zhangliang Zhu: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Masaru Tanokura: Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Takuya Miyakawa: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Satoshi Hachimura: Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo

DOI: https://doi.org/10.1038/s42003-022-03369-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

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β-elemene regulates the balance of proinflammatory cytokines in mouse white adipose tissue through MAPK signaling. Targets of β -elemene are predicted based on its 3D structure and include regulators of macrophage-mediated processes.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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