"STUDY OF Gc, Cp, C3 , IgG , IgA AND IgM LEVELS IN PATIENTS WITH ESOPHAGEAL CARCINOMA IN IRAN "

Abstract

Quantitative serum level measurements of Gc , Cp , C3 , IgG , IgA and 1gM were carried out on 102 patients with esophageal carcinoma following laryngectomy, in comparison with 66 healthy individuals as controls, in Gonbad area, north east of Iran. The procedure of radioinimuno-diffusion by standard M partigen plates was used for the measurements. A significant decrease was observed in Gc level in patients (P = 46.08%, C = 27.27%) (P=0.0145). An increase was observed in serum 1gM of patients (23.88%) in comparison 0 with the controls (12.19/o). A significant increase was observed in C3 level (P = 33.33% C = 4.76%) (P = 0.0205). Highly significant increase, over the maximum level, was seen in serum Cp, the copper carrying protein, in patient (36.49%) in comparison with the controls (2.5%) (P=0.0001). The measurements of IgG and IgA showed no difference between patients and controls. The correlation coefficient of all factors were calculated and compared with each other. A positive value was observed between Cp and IgG of patients, as the increase of one is directly proportional to the increase of the other. Gc versus 1gM in patients and controls showed negative correlation.

Keywords

• Esophageal cancer
• Immunoglobulins
• Serum proteins