Nature Communications (Aug 2021)
Neutralization of SARS-CoV-2 variants by convalescent and BNT162b2 vaccinated serum
- Timothy A. Bates,
- Hans C. Leier,
- Zoe L. Lyski,
- Savannah K. McBride,
- Felicity J. Coulter,
- Jules B. Weinstein,
- James R. Goodman,
- Zhengchun Lu,
- Sarah A. R. Siegel,
- Peter Sullivan,
- Matt Strnad,
- Amanda E. Brunton,
- David X. Lee,
- Andrew C. Adey,
- Benjamin N. Bimber,
- Brian J. O’Roak,
- Marcel E. Curlin,
- William B. Messer,
- Fikadu G. Tafesse
Affiliations
- Timothy A. Bates
- Department of Molecular Microbiology & Immunology, Oregon Health & Science University (OHSU)
- Hans C. Leier
- Department of Molecular Microbiology & Immunology, Oregon Health & Science University (OHSU)
- Zoe L. Lyski
- Department of Molecular Microbiology & Immunology, Oregon Health & Science University (OHSU)
- Savannah K. McBride
- Department of Molecular Microbiology & Immunology, Oregon Health & Science University (OHSU)
- Felicity J. Coulter
- Department of Molecular Microbiology & Immunology, Oregon Health & Science University (OHSU)
- Jules B. Weinstein
- Department of Molecular Microbiology & Immunology, Oregon Health & Science University (OHSU)
- James R. Goodman
- Medical Scientist Training Program, OHSU
- Zhengchun Lu
- Department of Molecular Microbiology & Immunology, Oregon Health & Science University (OHSU)
- Sarah A. R. Siegel
- OHSU-PSU School of Public Health, Program in Epidemiology
- Peter Sullivan
- OHSU-PSU School of Public Health, Program in Epidemiology
- Matt Strnad
- OHSU-PSU School of Public Health, Program in Epidemiology
- Amanda E. Brunton
- OHSU-PSU School of Public Health, Program in Epidemiology
- David X. Lee
- Department of Molecular Microbiology & Immunology, Oregon Health & Science University (OHSU)
- Andrew C. Adey
- Department of Molecular & Medical Genetics, OHSU
- Benjamin N. Bimber
- Vaccine and Gene Therapy Institute, OHSU
- Brian J. O’Roak
- Department of Molecular & Medical Genetics, OHSU
- Marcel E. Curlin
- Department of Medicine, Division of Infectious Diseases, OHSU
- William B. Messer
- Department of Molecular Microbiology & Immunology, Oregon Health & Science University (OHSU)
- Fikadu G. Tafesse
- Department of Molecular Microbiology & Immunology, Oregon Health & Science University (OHSU)
- DOI
- https://doi.org/10.1038/s41467-021-25479-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 7
Abstract
Here, the authors show that neutralization of human sera from both BNT162b2 vaccine recipients and from convalescent COVID-19 patients is less efficient against SARS- CoV-2 variants B.1.1.7 and B.1.351 and negatively associated with patient age.
