Case series of severe fetal hemolysis in Rh-C-negative mother

Abstract

Anti-Rh(c) antibody is the third most common cause of severe hemolytic disease of the fetus and newborn (HDFN). The widespread use of anti-D immunoglobulin has led to arelative increase in the importance of non-RhD isoimmunization as a cause of HDFN. The Rhc is a part of the Rh blood group system and its prevalence in India is 52%–62%. Here, we report two cases with anti-c antibody with severe hyperbilirubinemia who required intravenous immunoglobulin, red blood cells transfusion, and phototherapy.

Keywords

• anti-c
• hemolytic
• hemolytic disease of the fetus and newborn
• intravenous immunoglobulin
• phototherapy
• red blood cells transfusion