Immunomodulatory effects of exosomes from different resources on idiopathic pulmonary fibrosis

Abstract

Idiopathic pulmonary fibrosis （IPF） is a chronic progressive interstitial lung disease. The pathogenesis of IPF remains elusive. The theory that fibroblasts directly participate in the IPF process has been widely accepted. Moreover, studies have demonstrated that the incidence and development of IPF is intimately related to inflammatory and immunity, which is mainly manifested with the interaction between immune cells and fibroblasts. Exosomes are important carriers for biological information communication between cells, and exosomes from different cell sources can carry different signal factors, which serve a bridge between immune cells and fibroblasts, and play a role in the inflammatory response and immune regulation of IPF. Therefore, exosomes may become a vital pattern for clinical diagnosis and treatment of IPF. In this article, research progress on the roles of exosomes from different cell sources in IPF was reviewed, aiming to understand the roles of exosomes, as the carriers of information communication between cells, in regulating the incidence and progression of IPF.

Keywords

• |idiopathic pulmonary fibrosis|exosome|inflammatory|immunity|fibroblast|interstitial pneumonia