Serum apelin and galectin-3 in preeclampsia in Iraq

Abstract

Objective This study investigates the correlation between serum apelin and galectin-3 levels with insulin resistance (IR) in women with preeclampsia (PE). Methods Serum apelin, galectin-3, and insulin levels were measured in 60 PE women and 30 normotensive pregnant. Results The PE group had significantly lower apelin and higher galectin-3 levels than the control group. PE group exhibited dyslipidemia and had higher β-cell functions than the controls. Galectin-3 level correlates with insulin, glucose, and IR. High galectin-3 also is correlated positively with dyslipidemia. Conclusion In PE, there is a possible contribution of galectin-3 to the harmful effects of IR and dyslipidemia.

Keywords

• apelin
• galectin-3
• preeclampsia
• insulin resistance
• lipid profile