European Medical Journal Neurology (Jul 2014)

Apomorphine Penject – Emerging Evidence and Treatment Strategies for Delayed on and off Periods in Parkinson’s disease

  • Olivier Rascol,
  • Fabrizio Stocchi,
  • Stuart Isaacson,
  • William Ondo

Journal volume & issue
Vol. 2, no. 1
pp. 27 – 35


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This educational symposium was held during the Joint Congress of European Neurology (EFNS–ENS), which took place from 31st May to 3rd June 2014 in Istanbul, Turkey, and was sponsored by Britannia Pharmaceuticals Limited. The symposium debated the problem of delayed ON and OFF periods in Parkinson’s disease that can occur even in patients optimised on oral medication. Emerging evidence for the rapid and effective resolution of such complications using apomorphine intermittent injection (penject) was reviewed with particular reference to the positive results of the recent AM IMPAKT trial in patients with morning akinaesia. The discussions were illustrated with examples of ‘real life’ patient case studies to help determine which patients might be best suited for treatment with apomorphine injection.