Frontiers in Chemistry (Apr 2022)

Palladium-Mediated Hydroamination of DNA-Conjugated Aryl Alkenes

  • Kunliang Cai,
  • Yuzhao Ran,
  • Wenbo Sun,
  • Sen Gao,
  • Jin Li,
  • Jinqiao Wan,
  • Guansai Liu

DOI
https://doi.org/10.3389/fchem.2022.851674
Journal volume & issue
Vol. 10

Abstract

Read online

C-N bond formation is one of the most commonly used reactions in medicinal chemistry. Herein, we report an efficient Pd-promoted hydroamination reaction between DNA-conjugated aryl alkenes and a wide scope of aliphatic amines. The described reactions are demonstrated in good to excellent conversions to furnish C (sp3)–N bonds on DNA. This DNA-compatible transformation has strong potentials for the application into DNA-encoded library synthesis.

Keywords