Nature Communications (May 2020)
Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity
- Sangman M. Kim,
- Jennifer R. DeFazio,
- Sanjiv K. Hyoju,
- Kishan Sangani,
- Robert Keskey,
- Monika A. Krezalek,
- Nikolai N. Khodarev,
- Naseer Sangwan,
- Scott Christley,
- Katharine G. Harris,
- Ankit Malik,
- Alexander Zaborin,
- Romain Bouziat,
- Diana R. Ranoa,
- Mara Wiegerinck,
- Jordan D. Ernest,
- Baddr A. Shakhsheer,
- Irma D. Fleming,
- Ralph R. Weichselbaum,
- Dionysios A. Antonopoulos,
- Jack A. Gilbert,
- Luis B. Barreiro,
- Olga Zaborina,
- Bana Jabri,
- John C. Alverdy
Affiliations
- Sangman M. Kim
- Committee on Immunology, University of Chicago
- Jennifer R. DeFazio
- Department of Surgery, University of Chicago
- Sanjiv K. Hyoju
- Department of Surgery, University of Chicago
- Kishan Sangani
- Committee on Immunology, University of Chicago
- Robert Keskey
- Committee on Immunology, University of Chicago
- Monika A. Krezalek
- Department of Surgery, University of Chicago
- Nikolai N. Khodarev
- Department of Radiation and Cellular Oncology and The Ludwig Center for Metastasis Research, University of Chicago
- Naseer Sangwan
- Department of Surgery, University of Chicago
- Scott Christley
- Department of Surgery, University of Chicago
- Katharine G. Harris
- Department of Medicine, University of Chicago
- Ankit Malik
- Committee on Immunology, University of Chicago
- Alexander Zaborin
- Department of Surgery, University of Chicago
- Romain Bouziat
- Committee on Immunology, University of Chicago
- Diana R. Ranoa
- Department of Radiation and Cellular Oncology and The Ludwig Center for Metastasis Research, University of Chicago
- Mara Wiegerinck
- Department of Surgery, University of Chicago
- Jordan D. Ernest
- Department of Medicine, University of Chicago
- Baddr A. Shakhsheer
- Department of Surgery, University of Chicago
- Irma D. Fleming
- Department of Surgery, University of Chicago
- Ralph R. Weichselbaum
- Department of Radiation and Cellular Oncology and The Ludwig Center for Metastasis Research, University of Chicago
- Dionysios A. Antonopoulos
- Department of Medicine, University of Chicago
- Jack A. Gilbert
- Department of Surgery, University of Chicago
- Luis B. Barreiro
- Department of Medicine, University of Chicago
- Olga Zaborina
- Department of Surgery, University of Chicago
- Bana Jabri
- Committee on Immunology, University of Chicago
- John C. Alverdy
- Department of Surgery, University of Chicago
- DOI
- https://doi.org/10.1038/s41467-020-15545-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Sepsis due to multidrug resistant pathogens is the most common cause of death in intensive care units. Here, the authors report that fecal microbiota transplant (FMT) can rescue mice from lethal sepsis of pathogens isolated from stool of a critically ill patient and show that FMT reverses the immunosuppressive effect induced by the pathogen community.
