Case Report: Tissue Origin Identification for Cancer of Unknown Primary: Gene Expression Profiling Approach

Xingxiang Pu; Sa Yang; Yan Xu; Bolin Chen; Qianzhi Wang; Qian Gong; Lin Wu

doi:10.3389/fonc.2021.702887

Frontiers in Oncology (Nov 2021)

Case Report: Tissue Origin Identification for Cancer of Unknown Primary: Gene Expression Profiling Approach

Xingxiang Pu,
Sa Yang,
Yan Xu,
Bolin Chen,
Qianzhi Wang,
Qian Gong,
Lin Wu

Affiliations

Xingxiang Pu: Department of Thoracic Medical Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
Sa Yang: Department of Pharmacy, Xiangxiang People’s Hospital, Xiangxiang, China
Yan Xu: Department of Thoracic Medical Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
Bolin Chen: Department of Thoracic Medical Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
Qianzhi Wang: Department of Thoracic Medical Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
Qian Gong: Department of Pharmacy, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
Lin Wu: Department of Thoracic Medical Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China

DOI: https://doi.org/10.3389/fonc.2021.702887
Journal volume & issue: Vol. 11

Abstract

Read online

The treatment of cancer of unknown primary (CUP) is a huge challenge for clinicians. Gene expression profiling can help identify the tissue origin of tumors by detecting the expression levels of specific genes in tumor tissues. Herein, we report four CUP cases. All of them have been successfully identified with the corresponding primary tumor sites through gene expression profiling analysis. Then all patients received accurate treatment, providing reference to guide therapeutic decisions to treat CUP tumors in the future.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

About the journal

Abstract

Keywords