Characterization of Some Dermato-Cosmetic Preparations with Marine Lipids from Black Sea Wild Stingray
Magdalena Mititelu,
Monica Licu,
Carmen Elena Lupu,
Sorinel Marius Neacșu,
Gabriel Olteanu,
Gabriela Stanciu,
Doina Drăgănescu,
Carmen-Nicoleta Oancea,
Ștefan Sebastian Busnatu,
Lucian Hîncu,
Maria Viorica Ciocîlteu,
Dumitru Lupuleasa
Affiliations
Magdalena Mititelu
Department of Clinical Laboratory and Food Safety, Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila, 020956 Bucharest, Romania
Monica Licu
Department of Medical Psychology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
Carmen Elena Lupu
Department of Mathematics and Informatics, Faculty of Pharmacy, “Ovidius” University of Constanta, 6 Capitan Aviator Al. Serbanescu Street, Campus, C Block, 900001 Constanta, Romania
Sorinel Marius Neacșu
Department of Pharmaceutical Technology and Bio-pharmacy, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 020945 Bucharest, Romania
Gabriel Olteanu
Department of Clinical Laboratory and Food Safety, Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila, 020956 Bucharest, Romania
Gabriela Stanciu
Department of Chemistry and Chemical Engineering, Ovidius University of Constanta, 900527 Constanta, Romania
Doina Drăgănescu
Department of Pharmaceutical and Computer Physics, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 020956 Bucharest, Romania
Carmen-Nicoleta Oancea
Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy from Craiova, 200345 Craiova, Romania
Ștefan Sebastian Busnatu
Department of Cardio-Thoracic Pathology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
Lucian Hîncu
Department of Drug Industry and Pharmaceutical Biotechnologies Department, Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila, 020956 Bucharest, Romania
Maria Viorica Ciocîlteu
Department of Analytical and Instrumental Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Petru Rares Street, no. 2–4, 200638 Craiova, Romania
Dumitru Lupuleasa
Department of Pharmaceutical Technology and Bio-pharmacy, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 020945 Bucharest, Romania
The traditional knowledge about the therapeutic and nutritional value of fish has been unanimously recognized among the population since ancient times. So, thanks to the therapeutic virtues of these marine animals, it was possible to develop therapies for certain pathologies as well as the use of bioactive compounds as adjunctive therapies incorporated into the treatment regimen of patients. In the present study, stingray liver oil from wild species collected from the Romanian coast of the Black Sea was isolated and analyzed. Fatty acid analysis was performed by gas chromatography. The analysis of the distribution of fatty acids in the composition of stingray liver oil indicates a ratio of 2.83 of omega 3 fatty acids to omega 6, a ratio of 1.33 of polyunsaturated fatty acids to monounsaturated fatty acids, an iodine index of 111.85, and a total percentage of 68.98% of unsaturated fatty acids. Stingray liver oil was used to evaluate the healing action after preparing a fatty ointment. According to the experimental data, a complete regeneration capacity of the wounds was noted in 12 days without visible signs. Four emulgels with stingray liver oil were formulated and analyzed from a rheological and structural point of view in order to select the optimal composition, after which the anti-inflammatory effect on inflammation caused in laboratory rats was studied and an anti-inflammatory effect was found significant (a maximum inhibitory effect of 66.47% on the edemas induced by the 10% kaolin suspension and 65.64% on the edemas induced by the 6% dextran solution).
