PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA

Tovah A. Day; Jacob V. Layer; J. Patrick Cleary; Srijoy Guha; Kristen E. Stevenson; Trevor Tivey; Sunhee Kim; Anna C. Schinzel; Francesca Izzo; John Doench; David E. Root; William C. Hahn; Brendan D. Price; David M. Weinstock

doi:10.1038/ncomms15110

Nature Communications (Apr 2017)

PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA

Tovah A. Day,
Jacob V. Layer,
J. Patrick Cleary,
Srijoy Guha,
Kristen E. Stevenson,
Trevor Tivey,
Sunhee Kim,
Anna C. Schinzel,
Francesca Izzo,
John Doench,
David E. Root,
William C. Hahn,
Brendan D. Price,
David M. Weinstock

Affiliations

Tovah A. Day: Department of Medical Oncology, Dana-Farber Cancer Institute
Jacob V. Layer: Department of Medical Oncology, Dana-Farber Cancer Institute
J. Patrick Cleary: Department of Medical Oncology, Dana-Farber Cancer Institute
Srijoy Guha: Department of Medical Oncology, Dana-Farber Cancer Institute
Kristen E. Stevenson: Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute
Trevor Tivey: Department of Medical Oncology, Dana-Farber Cancer Institute
Sunhee Kim: Department of Medical Oncology, Dana-Farber Cancer Institute
Anna C. Schinzel: Genetic Perturbation Platform, Broad Institute of MIT and Harvard University
Francesca Izzo: Department of Medical Oncology, Dana-Farber Cancer Institute
John Doench: Genetic Perturbation Platform, Broad Institute of MIT and Harvard University
David E. Root: Genetic Perturbation Platform, Broad Institute of MIT and Harvard University
William C. Hahn: Department of Medical Oncology, Dana-Farber Cancer Institute
Brendan D. Price: Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School
David M. Weinstock: Department of Medical Oncology, Dana-Farber Cancer Institute

DOI: https://doi.org/10.1038/ncomms15110
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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Chromosomal rearrangements are key events in the pathogenesis of a range of disorders. Here the authors utilize a zinc finger nuclease translocation reporter to identify PARP3 as a regulator of these events at sites enriched for G quadruplex DNA.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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