Stability of 5 mg/mL Nitrendipine Oral Suspension in Syrspend® SF PH4

Abstract

Nitrendipine is prescribed to children for the treatment of primary hypertension (off-label use). Available specialties (Nidrel®, Baypress® and others generic drugs) are only marketed in tablet form, which is unsuitable for pediatric use. A hospital preparation of nitrendipine oral suspension at 5 mg/mL was developed. The aim of the study was to determine physicochemical and microbiological stability of the nitrendipine oral suspension in order to set a shelf life for the preparation.

Keywords

• pediatrics
• hypertension
• calcium-channel blockers
• stability
• hplc