Molecules
(Sep 2021)
Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-<i>a</i>]quinolines and 1,3,4-Oxadiazole Rings
Alexander V. Aksenov,
Nikita K. Kirilov,
Nicolai A. Aksenov,
Dmitrii A. Aksenov,
Elena A. Sorokina,
Carolyn Lower,
Michael Rubin
Affiliations
Alexander V. Aksenov
Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia
Nikita K. Kirilov
Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia
Nicolai A. Aksenov
Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia
Dmitrii A. Aksenov
Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia
Elena A. Sorokina
Organic Chemistry Department, Peoples’ Friendship, University of Russia (RUDN University), 6, Miklukho-Maklaya St., 117198 Moscow, Russia
Carolyn Lower
Department of Chemistry, University of Kansas, 1567 Irving Hill Road, Lawrence, KS 66045, USA
Michael Rubin
Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia
DOI
https://doi.org/10.3390/molecules26185692
Journal volume & issue
Vol. 26,
no. 18
Abstract
Read online
Nitroalkanes activated with polyphosphoric acid could serve as efficient electrophiles in reactions with amines and hydrazines, enabling various cascade transformations toward heterocyclic systems. This strategy was developed for an innovative synthetic protocol employing simultaneous or sequential annulation of two different heterocyclic cores, affording [1,2,4]triazolo[4,3-a]quinolines with 1,3,4-oxadiazole substituents.
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