Differences Platelets Count, IL-6, Aldosterone Level and Fatty Liver Occurrence Between Obese and Non-Obese Adult Young Women

Abstract

Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is common liver disease often found and occurs in community. Prevalence of liver disease (NAFLD) has risen rapidly along with an increase obesity incidence in women. Inflammation condition in obese condition causing an increase in IL-6, Platelets Count (PLTC), and Aldosterone level increased risk of developing NAFLD. Aim: To analyze differences IL-6, PLTC, and Aldosterone level between Obese and Non-Obese Women. Methods: This study was an observational cross-sectional analytical study that conducted in November-January 2021 at Diponegoro National Hospital (RSND) Semarang. Inclusion criteria for respondents in this study were being middle-aged women (30-49 years), healthy, and willing to take part in this study. Total respondent in this study was 60 people then divided into two groups that is Obese and Non-Obese Group. The degree of fatty liver was examined using the ultrasound method. Platelet count (PLTC) were measured by Indico Blood Analyzer. Meanwhile IL-6 and Aldosterone level analyzed by the enzyme-linked immunosorbent assay (ELISA) method. Fatty liver was diagnosed by abdominal ultrasound. Data were analyzed using SPSS 18.0 that including normality, different tests, and regression tests. Result: Incidence of fatty liver in the obese group was significantly different from the non-obese group (p<0.005). No significant difference average aldosterone serum, and AST between two group. Platelet Count (PLTC), IL-6 between two groups was showed significant difference between two groups. Conclusion: Obesity will trigger an increase in IL-6 and PLT which can increase the risk of fatty liver.

Keywords

• obesity
• nafld
• il-6
• platelete count
• aldosterone
• inflammation