Nature Communications (Sep 2020)

Elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF1

  • Hisashi Yoshida,
  • Sam-Yong Park,
  • Gyosuke Sakashita,
  • Yuko Nariai,
  • Kanako Kuwasako,
  • Yutaka Muto,
  • Takeshi Urano,
  • Eiji Obayashi

DOI
https://doi.org/10.1038/s41467-020-18559-6
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 9

Abstract

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U2AF1 binds to the 3’ splice site of introns and its mutation lead to abnormal splicing. Here the authors solve the crystal structures of wild type and pathogenic mutant U2AF1 bound to target RNA, showing that different target sequence is preferred by pathogenic mutant.